منابع مشابه
Building a spindle pole
astillo et al. (page 453) have identified what may be a key event in building the spindle pole body (SPB) of budding yeast. They found that the kinase Mps1p phosphorylates and thus helps organize Spc42p, an important component of the SPB central plaque. Mps1p has been a difficult protein to study, as it does double duty as a regulator of SPB structure, and as part of the spindle checkpoint sign...
متن کاملSpindle pole bodies
How did you become interested in plants? I began my graduate work with Phil Leder with the hope of making transgenic mice as a means towards understanding development in a multicellular organism. It turned out to be far more difficult and timeconsuming than I had bargained for. So when it became apparent that making transgenic plants was relatively easy, I jumped at the opportunity. I also thou...
متن کاملComponents of the yeast spindle and spindle pole body
Yeast spindle pole bodies (SPBs) with attached nuclear microtubles were enriched approximately 600-fold from yeast cell extracts. 14 mAbs prepared against this enriched SPB fraction define at least three components of the SPB and spindle. Immunofluorescent staining of yeast cells showed that throughout the cell cycle two of the components (110 and 90 kD) were localized exclusively to the SPB re...
متن کاملExit from Mitosis Spindle Pole Power
of mitosis when the bud cell body receives a progeny spindle pole. The signal that this has occurred is generated when a GTP binding protein located on the outside of the spindle pole is brought into the vicinity of an activator confined to the bud. Thus, the outcome of a motile process, mitotic spindle-mediated segregation of replicated chromosomes, is monitored spatially. To the observer, one...
متن کاملTpx2, a Novel Xenopus Map Involved in Spindle Pole Organization
TPX2, the targeting protein for Xenopus kinesin-like protein 2 (Xklp2), was identified as a microtubule-associated protein that mediates the binding of the COOH-terminal domain of Xklp2 to microtubules (Wittmann, T., H. Boleti, C. Antony, E. Karsenti, and I. Vernos. 1998. J. Cell Biol. 143:673-685). Here, we report the cloning and functional characterization of Xenopus TPX2. TPX2 is a novel, ba...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1563iti5